H-Locus (Harlequin)
The 20S proteasome β2 subunit (PSMB7) gene is responsible for the Harlequin coat pattern in Great Danes. This gene is also known as H-Locus. Harlequin is a pattern resulting from interaction of the Merle (M-locus) gene and the Harlequin (H-locus) gene on black pigment. The Harlequin gene can modify the Merle...
Read moreMutazione autosomica dominante
I cani mostrano un'ampia varietà di colori e schemi di mantello. A volte la classificazione di questi colori può essere fonte di confusione perché registri o associazioni diverse possono utilizzare nomi diversi per lo stesso colore. Due diversi pigmenti sono presenti in orni cane e sono alla base del loro...
Read moreS-Locus (Piebald)
The white spotting patterns that occur in many dog breeds do not have a uniform genetic basis. The Microphthalmia Associated Transcription Factor gene (MITF gene) is associated with many white spotting patterns. This gene is also known as the S-Locus. There are three major white spotting patterns described. One pattern...
Read moreE-Locus / Em-locus
Due diversi pigmenti sono presenti in orni cane e sono alla base del loro colore del mantello: pigmento nero (eumelanina) e pigmento rosso/giallo/crema (feomelanina). La produzione di pigmento nero e rosso/giallo/crema è controllata dal gene recettore della Melanocortina 1(MC1R), noto anche come gene Extension o Locus-E. Il test Colore del...
Read moreCo-Locus (Cocoa)
The Hermansky-Pudlak syndrome 3 (HPS3) gene, also known as cocoa coat colour or co-locus is responsible for the brown colour in French Bulldogs. Mutations of the HPS3 gene interfere with the eumalin (black pigment) synthesis, which results in brown-pigmentation. The brown colour caused by the HPS3-variants is known to darken...
Read moreB-locus
Il gene della Tyrosinase-Related Protein 1 (TYRP1), noto anche come gene Brown o Locus-B, controlla la diluizione del pigmento nero in marrone. Il gene TYRP1 non ha alcun effetto sul colore del pelo dei cani che sono omozigoti ee per il Locus-E in quanto non hanno pigmento nero, ma ha...
Read moreD-Locus / D-Locus Improved
The dilute gene (MLPH gene) is responsible for the intensity of the coat colour by affecting the distribution of melanin-containing cells. This gene is also known as the D-Locus and dilutes all colours. Besides the hair colour also the colour of the nose is diluted and the colour of the...
Read moreI-Locus
The MFSD12 gene, also known as I-Locus affects the expression of the pheomelanin (red) pigment. The MFSD12 gene has no effect on eumelanin (black) pigment, therefore the black coat and the black hair ends remain black. The mutation affects the pheomelanin in the entire coat resulting in a pure white...
Read moreA-Locus
The Agouti gene (ASIP gene) is responsible for the production of a protein that regulates the distribution of black pigment (eumelanin) within the hair shaft. This gene is also known as the A-locus and determines whether an animal expresses an agouti appearance, and if so what type, by controlling the...
Read moreK-Locus
The Beta-defensin gene (CBD103 gene) produces dominant black vs. brindle vs. fawn coat colours. This gene is also known as the K-locus or Dominant black gene. The coat colour is further complicated by the interaction with the E-locus and the A-locus (agouti). The Coat Colour K-Locus (H819) tests for the genetic...
Read moreM-Locus (Merle)
The Silver gene (SILV gene), also called premelanosome protein (PMEL17 gene) is responsible for Merle. This gene is also known as M-Locus. Merle only dilutes eumelanin (black) pigment; dogs with two copies of the allele e (homozygous e/e) at E-Locus have no black pigment, thus do not express merle. Merle...
Read moreSaddle tan vs black-and-tan
The hnRNP associated with lethal yellow gene (RALY gene) defines whether tan points or saddle tan is expressed in Basset Hounds and Pembroke Welsh Corgi dogs. Black and tan colour is characterized by light colour on the muzzle, above the eyes (tan points) and on the undersides of the dog...
Read morePanda White Spotting
A mutation in the KIT-gene is associated with a white spotting pattern in German Shepherd Dogs, this pattern is also called Panda White Spotting. The mutation is very recent, it appeared spontaneously in a female born in 2000. The gene for white-spotting is known as the S-locus (MITF-Gene), however this...
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