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Coat colour in dogs is controlled by a wide range of different genes working together.
Working days 10
Specifiche
| Breeds | Cane da pastore scozzese Shetland (Shetland Sheepdog), Levriero inglese, Levriero italiano, Mastino inglese, Mastino Tibetano, Mudi, Pechinese, Pumi, Chihuahua, Shih-Tzu, Yorkshire Terrier |
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| Gene | |
| Organ | |
| specimen | Tampone, Sangue in EDTA, Sangue in Eparina, Seme, Tessuto |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informazioni generali
Coat colour in dogs is controlled by a wide range of different genes working together. These genes are often referred to as ‘loci’. The Dilution, or D-Locus, corresponds to the gene for melanophilin, MLPH, which is involved in the distribution of pigment. Autosomal recessive mutations of the D-Locus result in a ‘dilution’ of dark coat colours, turning them lighter and more silvery.
Any combination of two mutant alleles will result in a diluted coat. This variant of the D-Locus mutation, designated as d^3, is found in breeds such as the Chihuahua, Hungarian Mudi and Hungarian Pumi, Italian Greyhound and Shih-Tzu.
Caratteristiche cliniche
Affected animals (two alleles with mutation; d/d) have diluted coat and nose colour and the eye colour lightens to amber. Black dilutes into grey, also called blue or charcoal. The coat ranges from silver to almost black, but all homozygous dogs have a blue nose. Chocolate/brown/liver dilutes into lilac/light tan/Isabella, whilst their noses vary from pink, liver to isabella. Red/yellow/cream dilutes into champagne.
Mutations in the D-locus can sometimes cause colour dilution alopecia, as the dilute coat colour is linked to hair loss (alopecia). The severity and occurrence of alopecia vary both within and between breeds, meaning only some dogs with d/d will develop hair loss and certain breeds are more prone to the condition. The variable presentation of this condition suggests that additional genetic or environmental factors contribute to its development. Affected dogs typically dispaly hair loss between four months and two years of age, and their coats may appear dry and dull.
Informazioni aggiuntive
Il colore del mantello è un tratto intricato che coinvolge una combinazione di più geni diversi. Il test per una serie di loci diversi fornirà la previsione più completa della genetica del colore del mantello di un cane.
È probabile che esistano ulteriori varianti non ancora scoperte della mutazione Locus-D.
Riferimenti
Pubmed ID: 32531980
Omia ID: 31