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Lavender Foal Syndrome (LFS, also called Lethal Coat Colour Dilution) is a genetic disorder that is most commonly seen in Arabian horses.
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Specifiche
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Pelo, Sangue in EDTA, Sangue in Eparina, Seme, Tessuto |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informazioni generali
Lavender Foal Syndrome (LFS, also called Lethal Coat Colour Dilution) is a genetic disorder that is most commonly seen in Arabian horses. It is caused by an autosomal recessive mutation in the Myosin VA (MYO5A) gene. This gene is responsible for producing a protein that plays a key role in intracellular transport, particularly within nerve cells. A mutation in this gene affects proper neurological development and function, leading to the symptoms associated with LFS. The disorder is lethal and animals with 2 copies of the mutation typically are stillborn or die shortly after birth.
Caratteristiche cliniche
Foals that are affected for LFS are characterized by a distinctive coat colour (lavender, pale pink, or silver) at birth. They are not able to stand or sit upright and may have a backward-arched neck. This may be caused by abnormal stretching of joints in the limbs, neck and back. In addition, seizures, stiff paddling leg movements and involuntary eye movement (nystagmus) are other observed symptoms due to affected neurological development.
Foals with LFS cannot be treated and will die shortly after birth or have to be euthanized on humane grounds.
Informazioni aggiuntive
Riferimenti
Pubmed ID: 20419149
Omia ID: 1501