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Cardiac Laminopathy (CLAM), a fatal heritable condition, has been described in the Nova Scotia Duck Tolling Retriever.
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Specifiche
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Tampone, Sangue in EDTA, Sangue in Eparina, Seme, Tessuto |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informazioni generali
Cardiac Laminopathy (CLAM), a fatal heritable condition, has been described in the Nova Scotia Duck Tolling Retriever. This variant is caused by a recessive mutation to the gene LMNA. CLAM can result in Dilated Cardiomyopathy (DCM), which is a disorder characterised by enlargement of the heart (especially of the left ventricle), poor myocardial contractility, and congestive heart failure.
Caratteristiche cliniche
I cani affetti possono sviluppare la DCM entro il primo anno di vita. I sintomi della DCM possono includere mancanza di appetito, letargia e ritmo cardiaco irregolare o comunque anormale. I cani affetti possono morire di insufficienza cardiaca improvvisa.
Informazioni aggiuntive
Riferimenti
Pubmed ID: 37925523
Omia ID: 2796